David J. Jenkins of the University of Toronto. This concept was developed to help people who wanted to rank carbohydrates based upon how they affected the blood glucose levels. Different carbohydrates are absorbed into the system in different manners and all take different times to break down and digest. Certain signs of diabetes include frequent urination, increased thirst and desire for fluids and may also include an increased appetite. In many cases, a person with Type II diabetes feels generally unwell but cannot figure out what is wrong. Symptoms can mirror the flu or other illnesses. If you are experiencing frequent thirst, excessive urination and a substantially increased appetite, have yourself checked out for diabetes. If untreated, the gum disease can lead to the infection of Periodontitis that can become so severe that it causes one to lose their teeth. Many people with diabetes as well as those with compromised immune disorders risk acquiring this disease. This is why it is so important to have your teeth examined by a dentist on a regular basis. An exercise regime is often recommended, which can be good for depression, but people with depression often have little energy to begin an exercise regime. As the depression continues, people often lose interest in monitoring their blood sugar levels and may even skip their medication. Symptoms of depression include a loss of pleasure in every day activities you used to enjoy as well as a change in appetite. So the person with diabetes has a choice, they can either lose their toe or their life. In most cases, they choose to lose the toe. In some cases, however, the gangrene has already spread to the foot. Plus, the amputation risks more infection. In many cases, not only does the person lose their toe, but their entire foot. Some insulin, such as Humalog, is very short acting and peaks within an hour after injection. Other insulin, such as Ultra Lente, is very long acting and peaks in 18 hours. There are three characteristics to insulin. Onset is the time it takes for the drug to reach the bloodstream and begin lowering the glucose.