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Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos
by: Kirsten Hawkins
Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.

Diagnosis of Sarcomatoid Mesothelioma:

The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.

For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).

The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.

About the author:
Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/for information on asbestos reform, mesothelioma lawsuit news, and more.


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Cancer Diet - Minerals
 by: Marilyn Bennett

A cancer diet needs a good balance of minerals because minerals are needed by all cells for proper function. Patients are often found to be mineral deficient, so this is an area of the diet that needs particular attention.

There are two classes of minerals. Macrominerals, such as the well known calcium, magnesium, sodium, potassium and phosphorus, and microminerals, such as boron, chromium, copper, iron, iodine, germanium, sulfur, silicon, vanadium, zinc, manganese and molybdenum.

The good news is we will get most of the minerals we need, provided we are eating a diet based on a wide variety of fruits and veggies, with the addition of nuts, seeds and grains.

Where we can get in to trouble is that minerals are washed out of soils with constant rain, and modern fertilizers don't usually contain the wide variety of minerals we need. Organic gardeners usually use rock minerals on their soils and this results in organic produce have a much higher and broader range of minerals.

Germanium is one micromineral that cancer patients are often low on. It is essential for immune function and is critical to tissue oxygenation. Cancer grows rapidly where there is low oxygenation of cells. Germanium is found in broccoli, celery, garlic, onions, rhubarb, sauerkraut and tomato juice as well as aloevera and ginseng.

Iodine deficiency has been linked to breast cancer in more than one study. Seasalt contains iodine and a variety of minerals rather than the isolated highly processed iodine additive in table salt. Asparagus, garlic, lima beans, soybeans, sesame seeds all contain natural iodine along with the nutrients needed for good absorption.

Large amounts of brassicas eg brussels sprouts, cabbage and cauliflower, along with peaches, pears and spinach can block absorption of iodine, so ensure there is a balance of iodine rich foods in your diet.

Selenium has been linked to cancer. Selenium and Vitamin E work together to attack free radicals. Selenium is critical for pancreatic function, and pancreatic enzymes are critical to the bodies ability to fight tumour activity. This mineral is generally found in meat and grains, however countries such as New Zealand and much of America is known to have selenium deficient soils.

As there have been several studies showing that good selenium levels have significantly reduced the risk of cancer, this is one mineral you want to have enough of.

Food sources that should be included frequently in a cancer diet are: brazil nuts, broccoli, brown rice, brewers yeast, chicken, kelp, onions, salmon, seafood, tuna, wheatgerm and whole grains. Garlic, chamomile, ginseng and parsley are all easy to use concentrated forms that can be added to the diet daily.

A couple of warnings:

Be very careful about self-dosing with minerals as several of them will block absorption of others if the dose is too high.

Again, eating a variety of foods, with particular notice taken of those that have high mineral levels is the safest way to go. If you wish to explore mineral supplementation further, talk to your naturopath or nutritionist. But whatever you do, don't ignore the importance of these vital elements to your well being.



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